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| 1 | Ursodiol 300mg
Generic name: Urso Size: 180
| $335.99 |  |
| | 2 | Ursodiol 300mg
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| | 3 | Ursodiol 300mg
Generic name: Urso Size: 60
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| | 4 | Ursodiol 300mg
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Urso prescription: Ursodiol is a naturally-occurring bile acid that is made by the liver in humans and is secreted in small quantities in bile. It is used to dissolve and prevent cholesterol gallstones and to treat primary biliary cirrhosis, a disease of the liver. Ursodiol blocks the enzyme in the liver that produces cholesterol and thereby decreases production of cholesterol by the liver and the amount of cholesterol in bile. It also reduces the absorption of cholesterol from the intestine. By decreasing the concentration of cholesterol in bile, ursodiol prevents the formation and promotes the dissolution of cholesterol-containing gallstones. The mechanism by which it acts in primary biliary cirrhosis is not clear. Ursodiol is used to prevent cholesterol gallstones from forming during rapid loss of weight. It also is used to dissolve cholesterol gallstones that do not contain calcium and are less than 2 cm in diameter. It does not dissolve gallstones that are composed of pigment rather than cholesterol. Ursodiol must be used for one or more years, and 50% of patients who have successful dissolution of their gallstones will have the gallstones return within five years. The likelihood of having successful dissolution of gallstones is low if partial dissolution is not seen within 12 months of starting treatment. Ursodiol also is used to treat primary biliary cirrhosis.
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Why is this drug prescribed?
Ursodeoxycholic acid is a chemical called a bile acid. It occurs naturally in bile and can be used to dissolve gallstones.
The liver produces bile which is stored in the gall bladder. Bile is released by the gall bladder to aid the digestion of fats. It consists of cholesterol dissolved within bile salts. Gallstones occur in the gall bladder as a result of too much cholesterol, or too few bile salts within the bile. The imbalance causes excess cholesterol to separate out of the bile and form stones.
Ursodeoxycholic acid causes gallstones to dissolve by a mechanism that is not fully understood. It is known to reduce the production of cholesterol by the liver and also to reduce the absorption of cholesterol from the gut. Both of these actions decrease the amount of cholesterol that passes into the bile. Also, since ursodeoxycholic acid is a bile acid itself, it increases the level of bile acids within the bile.
The combination of these two factors reverses the imbalance and stops the cholesterol separating out of the bile. The gallstones then begin to dissolve. This is a useful alternative for people who cannot have, or wish to avoid surgery. Treatment is continued for up to two years, depending on the size of the stone.
Treatments
* Dissolving certain types of gall stones
What side effects can this drug cause?
* Itching
* Diarrhoea
* Nausea and vomiting |
