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Isoniazid prescription: is used to prevent active tuberculosis in persons who have an abnormal skin test for tuberculosis or in combination with other drugs for the treatment of active tuberculosis. Isoniazid, or INH, is an anti-bacterial drug that has been used to prevent and to treat tuberculosis since 1952. Tuberculosis is an infectious diseased caused by a bacterium. Once the infection is acquired, it usually remains dormant in the lungs. Later, the infection may become active in the lungs and sometimes spreads throughout the body. Patients with a tuberculosis skin test that has recently become abnormal (demonstrating recent infection with tuberculosis) but a normal chest x-ray (demonstrating inactive infection) are given INH alone for 6-9 months. Patients with active infection on chest x-ray are given INH combined with other antituberculous drugs.
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This belongs to the group of medicines known as antituberculous drugs.
Isoniazid is used alongside other drugs to treat and prevent tuberculosis (TB).
Isoniazid is available in tablet, oral liquid and injection form.
Why is this drug prescribed?
Isoniazid is an antibiotic that is used to kill the bacteria that cause tuberculosis. It's exact mechanism of action is unknown but it is thought to prevent the bacteria from making components called mycolic acids which are needed to form cell walls. It also seems to combine with an enzyme which interferes with the cell metabolism of the bacteria. As a result of the disruption in it's metabolism and without a cell wall the bacteria die.
There are two stages in the treatment of tuberculosis. In the first two months after infection, treatment is aimed at killing as many bacteria as possible. Therefore several anti-TB drugs with different mechanisms of action are used in combination. After this time some of the drugs are stopped and the others are continued for a further four months to kill any remaining bacteria. Isoniazid is used in both stages of treatment.
The bacteria that cause TB are difficult to treat. By using drugs in combination, the bacteria can be targeted in different ways and hence treatment is more likely to be effective than a single drug alone. In addition, using different drugs make it less likely that bacteria will develop resistance to treatment.
Treatments
* Treatment of tuberculosis in combination with other drugs
What side effects can this drug cause?
* Allergy to active ingredients
* Seizures
* Loss of contact with reality
* Nausea and vomiting
* Inflammation of the liver
* "Pins and needles" sensation in hands and feet
* Sudden severe deficiency in the number of white blood cells in the blood
* Inflammation of the optic nerve which results in blurring of vision |
