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Glucophage prescription: Oral antidiabetic agent. This medicine is known as a biguanide which is indicated for non-insulin dependent (type 2) diabetes. The mode of action works mainly by inhibiting glucose production and reducing it''s absorption in the gut, hence lowering the blood sugar levels in diabetics. Metformin is the drug of choice in overweight patients in whom strict dieting has been unsuccessful or has failed to control diabetes. Hypoglycaemia (low blood sugar levels) is not a problem with this medicine, and it has a lower incidence of weight gain compared with other oral antidiabetic agents (e.g. sulphonylureas).
Glucophage use: Metformin is also used to regulate blood sugar levels. Metformin works in three ways: first, it reduces the amount of glucose (sugar) produced by your liver; second, it reduces the amount of glucose absorbed from food through your stomach; and third, it makes the insulin that your body produces work better to reduce the amount of glucose already in your blood
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Why is this drug prescribed?
Glucophage tablets and Glucophage SR tablets both contain the active ingredient metformin hydrochloride. Metformin is also available without a brand name, ie as the generic drug. Metformin is used to help control blood sugar levels in people with type 2 or non-insulin dependent diabetes.
People with diabetes have a deficiency or absence of a hormone produced by the pancreas called insulin. Insulin is the main hormone responsible for the control of sugar in the blood. In type 2 diabetes the pancreas does not produce sufficient insulin and the cells of the body are resistant to the low levels of insulin circulating in the blood. Insulin would normally make the cells remove sugar from the blood, hence in type 2 diabetes blood sugar levels can rise too high.
Metformin hydrochloride is a type of antidiabetic drug known as a biguanide. It works in a number of ways to decrease the amount of sugar in the blood of people with type 2 diabetes.
Firstly, it reduces the amount of sugar produced by cells in the liver. Secondly, it increases the sensitivity of muscle cells to insulin. This enables the cells to remove sugar from the blood more effectively. Finally, it also delays absorption of sugar from the intestines into the bloodstream after eating. Overall, metformin reduces blood sugar levels both between and directly after meals.
Metformin is used as a first line treatment of type 2 diabetes in people who are overweight. It is used when diet and exercise have failed to control blood sugar levels. It can also be used in combination with other antidiabetic drugs to provide better control of blood sugar.
Glucophage tablets are standard release tablets that are taken two or three times a day either during or just after meals.
Glucophage SR tablets are prolonged release tablets that are designed to release metformin slowly and continuously over several hours. This produces a steady blood level of the drug throughout the day. The tablets are designed to be taken once or twice a day with meals, depending on your blood sugar control. They must be swallowed with water and not broken, chewed or crushed, as this would damage the prolonged release action.
Treatments
* Type 2 diabetes, when diet alone has failed to fully control blood sugar.
* Polycystic ovary syndrome.
What side effects can this drug cause?
* Disturbances of the gut such as nausea, vomiting, diarrhoea or abdominal pain.
* Loss of appetite.
* Metallic taste.
* Elevated levels of lactic acid in the blood.
* Decreased absorption of vitamin B12 during long-term use.
* Skin reactions such as rash, itching or flushing. |
