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Cymbalta prescription: Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It increases the amounts of serotonin and norepinephrine in the brain that help maintain mental balance and stop the movement of pain signals in the brain. As an anti-depressant, it shares its mechanism with venlafaxine (Effexor). Both of these medicines are related to the selective serotonin and norepinephrine reuptake inhibitor (SSRIs) - fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), and escitalopram (Lexapro). Similar to venlafaxine and the SSRIs, duloxetine is also effective in managing generalized anxiety disorder. Additionally, duloxetine has pain-reducing activity and has been used in the treatment of neuropathic pain associated with diabetic peripheral neuropathy. The mechanism responsible for its effectiveness in this pain state is not known, but is thought to involve its effects on serotonin and norepinephrine in the brain. Duloxetine is used for the treatment of depression, generalized anxiety disorder, and neuropathic pain associated with diabetic peripheral neuropathy.
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Why is this drug prescribed?
Cymbalta capsules contain the active ingredient duloxetine hydrochloride, which is a type of antidepressant known as a serotonin and noradrenaline reuptake inhibitor. This type of drug acts on nerve cells in the brain.
In the brain there are numerous different chemical compounds called neurotransmitters. These act as chemical messengers between the nerve cells. Serotonin and noradrenaline are two such neurotransmitters and have various functions that we know of.
When serotonin and noradrenaline are released from nerve cells in the brain they act to lighten mood. When they are reabsorbed into the nerve cells, they no longer have an effect on mood. It is thought that when depression occurs, there may be a decreased amount of serotonin and noradrenaline released from nerve cells in the brain.
Duloxetine works by preventing serotonin and noradrenaline from being reabsorbed back into the nerve cells in the brain. This helps prolong the mood lightening effect of any released serotonin and noradrenaline. In this way, duloxetine helps relieve depression.
It may take between two to four weeks for the benefits of this drug to appear, so it is very important that you keep taking it, even if it doesn't seem to make much difference at first. If you feel your depression has got worse, or if you have any distressing thoughts or feelings in these first few weeks, then you should talk to your doctor |