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Avandia prescription: Rosiglitazone, combined with diet, exercise, weight control and cessation of smoking is used for treating type II diabetes. Rosiglitazone may be used alone or in combination with other types of anti-diabetic drugs such as metformin or sulfonylureas as well as insulin. Since it requires naturally-secreted insulin to be effective, rosiglitazone is not recommended for use in type I diabetes where the amount of insulin is very low or absent. Rosiglitazone is an oral drug that reduces the amount of sugar (glucose) in the blood. It is used for treating patients with type 2 diabetes and is in a class of anti-diabetic drugs called thiazolidinediones. The other member of this class is pioglitazone (Actos). Insulin is a hormone produced by the pancreas that is important for controlling the levels of glucose in the blood. Insulin stimulates the cells of the body to remove glucose from the blood and thereby lowers the level of glucose in the blood. Patients with type II diabetes cannot make enough insulin. As a result, the cells in their bodies do not remove enough glucose from the blood, and the level of glucose rises. Rosiglitazone often is referred to as an 'insulin sensitizer' because it attaches to the insulin receptors on cells throughout the body and causes the cells to become more sensitive (more responsive) to insulin and remove more glucose from the blood. At least some insulin must be produced by the pancreas in order for rosiglitazone to work) Avandia use: Rosiglitazone is an antihyperglycemic agent. It helps the body respond better to insulin and it reduces the amount of sugar produced by the liver. It can help control blood sugar levels. Rosiglitazone is used, along with diet and exercise, in the treatment of non-insulin-dependent diabetes mellitus (type II diabetes). Rosiglitazone may also be used with a sulfonylurea (e.g., Diabeta, Glucotrol, Micronase, others), metformin (Glucophage)...
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Why is this drug prescribed?
Avandia tablets contain the active ingredient rosiglitazone maleate, which is an antidiabetic drug used to treat people with type 2 or non-insulin dependent diabetes.
People with diabetes mellitus have a deficiency or absence of a hormone produced by the pancreas called insulin. Insulin is the main hormone responsible for the control of sugar in the blood. In type 2 diabetes, the pancreas does not produce sufficient insulin and the cells of the body are resistant to the low levels of insulin circulating in the blood. Insulin would normally make the cells remove sugar from the blood, hence in type 2 diabetes blood sugar levels can rise too high.
Rosiglitazone is a type of antidiabetic drug known as a thiazolidinedione or glitazone. It helps to lower blood sugar levels by increasing the sensitivity of liver, fat and muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively.
Rosiglitazone also preserves the functioning of the cells in the pancreas that produce insulin.
The overall effect of this drug is therefore to help the body control blood sugar levels and prevent them becoming too high.
Treatments
* Type 2 diabetes
Rosiglitazone is used to treat people with type 2 diabetes, particularly overweight people, whose blood sugar is not sufficiently controlled by diet and exercise alone, and who cannot take metformin. Metformin is the standard first-line drug for overweight people with type 2 diabetes whose blood sugar is not controlled by diet alone.
Rosiglitazone can also used for people with type 2 diabetes whose blood sugar is not controlled by the maximum doses of either metformin, or another type of antidiabetic drug known as a sulphonylurea, for example gliclazide. In these cases rosiglitazone is added to treatment with the oral antidiabetic already being taken.
Rosiglitazone can be used as dual therapy in combination with metformin, as dual therapy in combination with a sulphonylurea, or as triple therapy in combination with metformin AND a sulphonylurea.
What side effects can this drug cause?
* Low blood glucose level
* Excessive fluid retention in the body tissues, resulting in swelling
* Constipation
* Low red blood cell count
* Increase in the level of fats, eg cholesterol, in the blood
* Headache
* Weight gain
* Increased appetite
* Fatigue
* Dizziness
* Pain in the muscles
* Pins and needles
* Difficulty in breathing
* Heart failure
* Decrease in the number of platelets in the blood
* Abnormal liver function
* Fluid in the lungs
* Swelling of the back of the eye |